Quinn Bonafiglia, Laboratory Medicine and Pathobiology
Year of Study: 2nd year
Student's Name: Quinn Bonafiglia
Graduate Department: Laboratory Medicine & Pathobiology
Country of Origin: Grimsby, Ontario, Canada
Country of Residence: Toronto, Ontario, Canada
Pre-MSc/PhD Education: Honours BSc Life Sciences, Queen’s University
Recent Research Experience: MSc, Neuroscience, Queen’s University. My MSc project focussed on how epigenetic regulation of gene expression influenced the phenotype of intestinal smooth muscle cells (ISMC), and how this mechanism may drive the dysfunction of ISMC and enteric neurons in inflammatory bowel disorder. This project involved the use of various cell culture techniques, functional assays, and tests of gene expression including qPCR, immunoblotting and immunofluorescence.
Current Research: My PhD project is aimed at assessing the role of a collagen binding receptor, discoidin domain receptor 1 (DDR1), in regulating the normal structure and function of the heart. In particular, I am interested in how DDR1 may regulate cell-cell and cell-matrix interactions and cardiac fibrosis in the normal and diseased heart. My project principally involves the use of animal models to assess the structural and functional impact of DDR1 on the heart.
Why Faculty of Medicine: I chose to pursue my PhD with the Faculty of Medicine for its renowned reputation in carrying out innovative and high-quality research. The research facilities and training environment greatly support my advancements in both education and research.
Future Education Plans and/or Career Goals: I plan on continuing a career in cardiovascular research with the hopes of staying involved with broadening our understanding of cardiac disease etiologies and therapies.
Contact Ambassador Quinn Bonafiglia